True Blue may mean:

• True Blue (album), an album by Madonna
• True Blue (Australian song), a song by John Williamson
• True Blue (TV series), a television series
• True Blue (system), part of Credion Corporation
• True Blue (song), a song by Madonna from the album of the same name
• True Blue (play), a play by Benjamin George premiered 2005 Off-Broadway
• Oxford Boat Race Mutiny, a book by Dan Topolski and Patrick Robinson about the 1987 Oxford-Cambridge Boat Race
• True Blue (film), a 1996 film based on above book
• True Blue (band), had a top 30 UK hit in 2000 with "Wassup"

See also the symbolism of the colour blue.