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Tranylcypromine (sold under the brand name Parnate®) is a monoamine oxidase inhibitor (MAOI) used as an antidepressant drug.
Pharmacology
Tranylcypromine is a non-hydrazine, irreversible monoamine oxidase inhibitor, and has a rapid onset of action.
The antidepressant activity of tranylcypromine is thought to be due to the fact that it increases the concentration of epinephrine, norepinephrine, and serotonin throughout the nervous system. This is achieved through the inhibition of monoamine oxidase.
Indications
Tranylcypromine is used for the treatment of major depressive episodes, without melancholia.
Contraindications
As with other MAOIs, those who are taking tranylcypromine must adhere to rigid dietary specifications in order to prevent complications.
Overdose
Symptoms of tranylcypromine overdose may include: insomnia, restlessness, anxiety, agitation, mental confusion, hypotension, dizziness, weakness, somnolence, hypertension, and headache.
Foods high in tyramine can precipitate hypertensive crisis. Tyramine can be found in cheeses, wine, and certain meats. MAOIs inhibit tyramine breakdown, thus dietary intake should be avoided.
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