Thyronamines are decarboxylated and deiodinated metabolites of the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3).

The thyronamine 3-iodothyronamine (T₁AM) is a natural, high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a G-protein-coupled receptor. In rodents, T₁AM causes a rapid drop in body temperature when injected.

See also

• Trace amine
• Thyroid hormone

References

• Nat. Med. 10(6):638-642 (2004) 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone PMID 15146179
• J. Med. Chem. 49(3):1101-1112 (2006) Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues PMID 16451074