N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N' '-triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. It's main toxicity is myelosuppression.

References

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Clinical Studies of triethylenephosphoramide compounds with nitrogen mustard-like activity. Sykes M et al, Cancer 1953; 6:142-148.

Chemistry, pharmacology and pharmacokinetics of ThioTEPA, M.J.Van Maanen et al, Cancer Treatment Reviews 2000, 26:257-268