Telicomys is an extinct genus of rodent from South America.

With a length of 2 m (6 ft 8 in), Telicomys is one of the largest rodents that ever lived, along with Phoberomys and the giant beaver. It is part of the same South American radiation of rodents as both Phoberomys and the modern capybara, which is the largest living rodent, reaching lengths of up to 1,35 m (4 ft 6 in). The closest living relative to Telicomys is the pacarana.

Prehistoric rodents | Hystricognath rodents