Southpaw is a colloquial term for left-handedness. Other meanings include:

• Southpaw (mascot), a mascot of the Chicago White Sox.
• "Southpaw", a 1978 song by Pink Lady.
• The Southpaw, a 1953 baseball novel by Mark Harris.
• Southpaw engine, a video game engine for the Game Boy Advance.
• Southpaw Grammar, a 1995 album by Morrissey.