Sophene was a province of the Roman Empire in modern-day southeastern Turkey. The capital was Amida (modern Diyarbakır).

Pompey had given Sophene to Tigranes, after defeating his father Tigranes the Great.Richardson, Peter, Univ of South Carolina Press, 1996, p. 96 Sophene later become part of the Roman Empire. Around 54, the province was ruled by Gaius Julius Sohaemus.Swain, Simon, Hellenism and Empire: Language, Classicism, and Power in the Greek World, Ad 50-250, Oxford University Press, 1996, p. 304. In 530, Sophene was included into the province of Armenia IV.Joshua, The Chronicle of Pseudo-Joshua the Stylite, Liverpool University Press, 2001, p. 54

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