| Name
| Term of Offices
| President(s) served under
|
| Alan Stephenson Boyd
| January 16, 1967 - January 20, 1969
| Lyndon Johnson
|
| John Anthony Volpe
| January 22, 1969 - February 1, 1973
| Richard Nixon
|
| Claude Stout Brinegar
| February 2, 1973 - February 1, 1975
| Nixon
|
| John W. Barnum (acting)
| February 2, 1975 - March 6, 1975
| Nixon
|
| William Thaddeus Coleman, Jr.
| March 7, 1975 - January 20, 1977
| Gerald Ford
|
| Brock Adams
| January 23, 1977 - July 20, 1979
| Jimmy Carter
|
| W. Graham Claytor, Jr. (acting)
| July 21, 1979 - August 14, 1979
| Carter
|
| Neil Goldschmidt
| August 15, 1979 - January 20, 1981
| Carter
|
| Andrew L. Lewis, Jr.
| January 23, 1981 - February 1, 1983
| Ronald Reagan
|
| Elizabeth Hanford Dole
| February 7, 1983 - September 30, 1987
| Reagan
|
| James H. Burnley IV (acting)
| October 1, 1987 - December 2, 1987
| Reagan
|
| James H. Burnley IV
| December 2, 1987 - January 30, 1989
| Reagan
|
| Samuel K. Skinner
| February 6, 1989 - December 13, 1991
| George H. W. Bush
|
| James B. Busey IV (acting)
| December 14, 1991 - February 23, 1992
| G. H. W. Bush
|
| Andrew Card
| February 24, 1992 - January 20, 1993
| G. H. W. Bush
|
| Federico Peña
| January 21, 1993 - February 14, 1997
| Bill Clinton
|
| Rodney Slater
| February 14, 1997 - January 20, 2001
| Clinton
|
| Mortimer L. Downey (acting)
| January 21, 2001 - January 24, 2001
| George W. Bush
|
| Norman Mineta
| January 25, 2001 - July 7, 2006
| G. W. Bush
|
| Maria Cino (acting)
| July 8, 2006–
| G. W. Bush
|
"United States Secretary of Transportation"