Regina may refer to:

• Regina, Latin word for queen. Often used to represent the legal fiction of the Crown as a legal concept in Commonwealth realms.

• Juno Regina, queens of the gods in Roman mythology.

• Regina, the Italian word for queen, derived directly from the Latin above.
  • Regina, Saskatchewan, the capital of the Canadian province of Saskatchewan.
• Regina, a former Canadian federal electoral district in the province of Saskatchewan.
• HMCS Regina, a Halifax-class frigate of the Canadian Navy
• Regina, New Mexico
• Regina (saint) Catholic martyr
• Regina (opera) a twentieth-century opera by Marc Blitzstein
• Saint Regina ecclesiastical division in Saskatchewan
• Rexx, open-source REXX interpreter for Linux, BSD, Windows, etc.
• Regina Encarnacion Ansong Velasquez, also known as Regine Velasquez (Asia's Songbird), is a singer, actress, model, entrepreneur, concert and stage director, and record producer from the Philippines.
• Popular singer Regina (Regina Richards), whose only hit song, "Baby Love", reached #10 in the U.S. in 1986.
• Regina, a concubine of Charlemagne
• Regina (program), a suite of mathematical software for 3-manifold topologists.
• Regina, Regina, a country music duo in the mid 90's.
• Regina, the protagonist in the Dino Crisis and Dino Crisis 2 video games by Capcom.
• Regina (genus), a genus of snakes.

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