Quark can refer to:

• quark, a subatomic particle
• "quark", a nonce word in James Joyce's Finnegans Wake
• quark (food), a soft cheese
• Quark, Inc., a software manufacturer best known for the page layout software QuarkXPress
• Quark (Star Trek), a character from the television series Star Trek: Deep Space Nine
• A Quark, a type of robot appearing in the television series Doctor Who
• Quark, an Italian scientific TV show by Piero Angela
• Quark, a character in the Danish comics series Valhalla
• Quark (kernel), a microkernel used in the MorphOS operating system
• Quark (chess), a chess engine
• Quark (TV series), a short-lived 1978 science fiction sitcom
• QuArK, an abbreviation for Quake Army Knife
• Quark (anthology series), a science fiction anthology book series printed in 1970 and 1971
• Quark (magazine), a 1970s popular science and puzzle magazine
• Quark is the name of a Marvel Comics character often associated with Longshot.
• a quark, an integer representing a string in the X Window System (see X resources)
• a quark, a kind of creature in the CG animated serial "Les Quarks" (1991) created by Benayoun, Schuiten and Peeters and made for 35mm release by Z.A. Productions.
• Quark is the name of the Szalinski family's dog in Honey, I Shrunk the Kids

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