Phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P₂) is a minor phospholipid component of cell membranes. PtdIns(4,5)P₂ is enriched at the plasma membrane where it is an important substrate for a number of important signalling proteins.

Phospholipase C hydrolyzes the phosphodiester link in PtdIns(4,5)P₂ forming inositol 1,4,5-triphosphate (InsP₃) and diacylglycerol (DAG).

Class I PI 3-kinases phosphorylate PtdIns(4,5)P₂ forming phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P₃).

See also

• Phosphatidylinositol
• Phosphatidylinositol 3-phosphate
• Phosphatidylinositol 4-phosphate
• Phosphatidylinositol 5-phosphate
• Phosphatidylinositol (3,4)-bisphosphate
• Phosphatidylinositol (3,5)-bisphosphate
• Phosphatidylinositol (3,4,5)-trisphosphate

References