Progestagens (also spelled progestogens or gestagens) are hormones which produce effects similar to progesterone, the only natural progestagen. All other progestagens are synthetic and are often referred to as progestins.

All progestagens have antiestrogenic (counteracting the effects of estrogens on the body) and antigonadotropic (inhibiting the production of sex steroids by gonads) properties.

Progestagens differ in their potency (affinity for progesterone receptors) and side effects. Such side effects may be androgenic (medroxyprogesterone and most C19 progestagens), antiandrogenic (cyproterone acetate), estrogenic, glucocorticoid (some C21 progestagens) or antimineralocorticoid (progesterone).

Uses

• Birth control
  • Most progestagens are used for their antiestrogenic properties in oral contraceptives to avoid overstimulation of the endometrium which could lead to endometriosis.
  • Medroxyprogesterone acetate (brand name Depo Provera) is used by depot injection.
  • Etonogestrol is released by subcutaneous implants (Implanon®). Similar products (Norplant® and Jadelle® contain levonogestrol.
• Antiandrogen
  • E.g. Cyproterone.

Progestagens | Sex steroids

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