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Prevnar is a a seven-valent pneumococcal conjugate vaccine. Prevnar is manufactured by Wyeth to protect infants and young children against pneumococcal disease. The valencies of Prevnar are serotypes of bacteria from which surface molecules are taken. In particular, Prevnar contains the cell membrane sugars of seven serotypes of Streptococcus pneumonia, combined with Diphtheria proteins. Prevnar does not contain living ingredients.
Centers for Disease Control recommendation
In 2001, the Centers for Disease Control (CDC), upon advice from its Advisory Committee on Immunization Practices added this vaccine to the US vaccination schedule.
Clinical study
Prevnar was administered to nearly 20,000 children before licensure. No unusual pattern of events was found.
Efficacy
Prevnar's efficacy has been demonstrated by research that found seven percent fewer new earaches and 0.1% fewer instances of invasive pneumococcal disease. Studies suggest that Prevnar may interfere with the efficacy of two other vaccines (pertussis and IPV) and may interfere with the Varicella and MMR vaccine.
Prevnar is directed for administration to immune-suppressed children.
References
- Shinefield HR, Black S, "Efficacy of pneumococcal conjugate vaccines in large scale field trials". Pediatr Infect Dis J. 2000 Apr;19(4):394-7 Pubmed
- Black S, Shinefield H, Fireman B, Lewis E, Ray P, Hansen JR, Elvin L, Ensor KM, Hackell J, Siber G, Malinoski F, Madore D, Chang I, Kohberger R, Watson W, Austrian R, Edwards K, "Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children". Northern California Kaiser Permanente Vaccine Study Center Group. Pediatr Infect Dis J 2000 Mar;19(3):187-95 Pubmed
- Lieu TA, Ray GT, Black SB, Butler JC, Klein JO, Breiman RF, Miller MA, Shinefield HR, "Projected cost-effectiveness of pneumococcal conjugate vaccination of healthy infants and young children". JAMA 2000 Mar 15;283(11):1460-8
- Shinefield HR, Black S, Ray P, Chang I, Lewis N, Fireman B, Hackell J, Paradiso PR, Siber G, Kohberger R, Madore DV, Malinowski FJ, Kimura A, Le C, Landaw I, Aguilar J, Hansen J, "Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers". Pediatr Infect Dis J 1999 Sep;18(9):757-63
External links
- 909Shot.com - 'Pneumococcal Disease and Vaccine', National Vaccine Information Center (NVIC)
- 'Prevnar Vaccine: Nearly Half a Billion In Sales Last Year', Tim O'Reiley, Daily Record (March 5, 2001)
- NCCN.net - 'Critique of Prevnar Vaccine', Michael Horwin, MA (September 19, 2000)
- http://www.medscape.com/viewarticle/466298?mpid=22855 - Prevnar alters middle ear pathogens
"Prevnar"