Potomac may refer to:

• Potomac River, which flows through West Virginia, Maryland, Virginia, and Washington, DC, USA
• Potomac, Maryland, an unincorporated area in Montgomery County, Maryland, USA
• Potomac, Virginia, an extinct town formerly located in Arlington County, Virginia, USA
• Potomac, Illinois, a village in Vermilion County, Illinois, USA
• Potomac Park, Maryland
• Potomac Highlands of West Virginia, a region of the Potomac River's watershed in West Virginia, USA
• Potomac Airfield, a general aviation airport located in Fort Washington, Maryland
• Potomac (tribe), a tribe of Native Americans
• A general term given to the Washington, D.C./Maryland metropolitan area
• One of several US Navy ships, including:
  • USS Potomac (1819), a frigate built in 1819
  • USS Potomac (AT–50), a tug commissioned in 1898
  • USS Potomac (AG-25), Franklin Delano Roosevelt’s presidential yacht commissioned in 1936
• The asteroid (1345) Potomac

In addition, Potomac Street is a major arterial in Aurora, Colorado and in Georgetown, D.C.

Potomac