Pleckstrin homology domain (PH domain) is a protein region of approximately 120 amino acids that can bind phosphoinositides (such as inositol 1,4,5-trisphosphate and phosphatidylinositol 4,5-bisphosphate), the βγ-subunits of heterotrimeric G proteins and protein kinase C. Through these interactions, the PH domain plays a role in the membrane recruitment of proteins containing the PH domain, thus targeting them to appropriate cellular compartment or enabling them to interact with other components of the signal transduction pathways.

External links

• PH domain entry in the SMART database
• Nash Lab Protein Interaction Domains - PH domain description

Protein domains