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PLC may stand for:
In technology:
- Packet Loss Concealment, a technique to mask the effects of missing packets in VoIP communications
- Power line communication, including broadband PLC modes
- Programmable logic controller, a small special-purpose computer used to automate machines
In business:
- Product life cycle, the succession of stages a product goes through
- Public limited company, in UK or Ireland, a type of limited company whose shares may be sold to the public
In medicine:
- Pityriasis lichenoides chronica, the chronic version of the Pityriasis lichenoides et varioliformis acuta
- Phospholipase C, a class of Phospholipase
In politics:
- Palestinian Legislative Council, law-making body of the Palestinian Authority
- Parti Libéral du Canada, the French name of the Liberal Party of Canada
- Partido Liberal Constitucionalista, the Spanish name of the Constitutional Liberal Party of Nicaragua
In linguistics:
- Prague linguistic circle, an influentual school of linguistic thought
- Phonetic loan character, an etymologic category of Chinese characters
In other contexts:
- Polish-Lithuanian Commonwealth (1569-1795), a federal monarchic republic formed by Poland and the Lithuania
- Platoon Leaders Class, the United States Marine Corps training program for Marine Officer Candidates
- Presbyterian Ladies' College or Pymble Ladies' College, the names of several independent girls' schools in Australia
- Psycho le Cemu, a Japanese visual kei rock band
- Patrol Leaders' Council, the leadership body in a Boy Scout Troop
"PLC"