Novel antidepressants are antidepressants exhibiting a mode of action beyond the already-established categories.

Agomelatine is such as case.

Certain medications generally not thought of as antidepressants are also sometimes used off-label for their potential mood-modifying action. Examples include the pain-killers hydrocodone and tramadol and the stimulants in the amphetamine class, among others. It is important to note that these are not considered novel antidepressants.

Antidepressants