A nerve is a part of the nervous system.

Nerve may also refer to:

• Nerve (website), a website and magazine
• Nerve of an open covering, a construction in mathematical topology
• Nerve of a category, a construction in category theory
• The Nerves, a '70s power-pop who were the original performers of "Hanging on the Telephone", a later hit for Blondie
• Nerve Software, a video game developer
• Nerve (magazine), a Liverpool-based arts and social issues magazine
• NERV, an organization in Neon Genesis Evangelion