Natchez may refer to:

• Natchez, Mississippi, a town in the United States
• Natchez people, a Native American nation
• Natchez language, the language of that tribe
• Natchez Trace, a trail from Natchez, Mississippi to Nashville, Tennessee
• Natchez Trace Parkway, a road that follows that trail
• S.S. Natchez, a paddlewheel steamship
• Les Natchez, a novel by French author François-René de Chateaubriand