Nanticoke is the name of several places in North America:

• Nanticoke in Maryland, United States
• Nanticoke in New York, United States
• Nanticoke in Pennsylvania, United States
• Nanticoke in Ontario, Canada

Nanticoke could also refer to:

• Nanticoke, an Algonquian language last spoken by Lydia Clark.
• The Nanticoke, an Algonquian tribe, whose name is derived from a word meaning People of the Tidewater, originally living in what is now eastern Maryland and southern Delaware. The Nanticoke have ben recognized as a tribe by the state legislature of Delaware since 1904.
• The Nanticoke River is a tributary of the Chesapeake Bay, in Maryland.
• Nanticoke Generating Station, in Haldimand, Ontario.