The Mono Basin is an endorheic basin located East of Yosemite National Park in California, United States. It is bordered to the West by the Sierra Nevada, to the East by the Cowtrack Mountains, to the North by the Bodie Hills, and to the South by the North ridge of the Long Valley Caldera.

Principal features of the Basin include Mono Lake, the Mono-Inyo Craters, the Aeolian Buttes, and the town of Lee Vining, CA.