Minusinsk () is a historic town in Krasnoyarsk Krai, Russia, situated on the Yenisei River at . Population: 72,561 (2002 Census); 69,000 (1985 est.); 44,500 (1973).

The settlement of Minyusinskoye () was founded in 1739, at the confluence of the Minusa River with the Yenisei. Turkic Min Usa means "my brook" (or "thousand rivers" [http://rfdata.al.ru/auto/city/13/559.HTM). It was renamed to Minusinskoye () in 1810. In 1822, it received a town status and renamed to Minusinsk of the Yenisei guberniya. It was one of the regional centers of farming and transit trade in East Siberia. The town was also a place of political exile. Vladimir Lenin used to visit Minusinsk on numerous occasions when he was in exile in a village of Shushenskoye between 1897 and 1900. During the Russian Civil War, Minusinsk was a stage for the Minusinsk Rebellion in 1918.

The Martyanov Natural History Museum, founded in 1877, is located in Minusinsk.

The area of Minusinsk is the location of the early Bronze Age Afanasevo culture.

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