Mackinaw or related spellings is the name of several different places and things, mostly related to the area where Lake Michigan meets Lake Huron. Mackinac is a derivation of the Native American "Michilimackinac" and is pronounced MACK-in-awe.

• Michilimackinac was a term for the entire region around the Straits of Mackinac
• Mackinac Bridge bridges the straits for road traffic.
• Straits of Mackinac connects the lakes and separates the Upper and Lower Peninsulas of Michigan
• Mackinac Island, an island in the straits which bans automobiles
• Mackinaw City, Michigan, village on the south side of straits
• Mackinaw Township, Michigan
• Fort Michilimackinac, a British fort on the south side of the straits
• Mackinac Island State Park, which preserves a large part of the island
• Fort Mackinac, a British, later American fort on the island
• Mackinac County, Michigan, in the Upper Peninsula
• Mackinac Ferry spans/spanned the straits for other traffic including railroad
• Mackinac Point, perhaps the northernmost point in the Lower Peninsula of Michigan
• Mackinac Point Lighthouse
• USCGC Mackinaw (WAGB-83), a United States Coast Guard icebreaker on the Great Lakes commissioned from 1944 to 2006
• USCGC Mackinaw (WLBB-30), a United States Coast Guard icebreaker on the Great Lakes to be commissioned June 10, 2006
• Mackinaw boat, a type of small sailboat used in the Upper Great Lakes
• Mackinaw cloth, a heavy wool cloth
• Mackinac Center for Public Policy, a nonpartisan research and educational organization advocating free-market policies
• Mackinaw Fur Company, founded by John Jacob Astor
• Mackinaw River, a tributary of the Illinois River
• USS Mackinac (AVP-13), a United States Navy seaplane tender commissioned from 1942 to 1946, later used by the United States Coast Guard from 1949 to 1967, where redesignated USCGC Mackinac (WAVP-371), and then (WHEC-371)
• USS Mackinaw, a United States Navy gunboat commissioned twice between 1864 and 1867

There are also two Mackinaw sailboat races, the Port Huron to Mackinac Boat Race and the Chicago to Mackinac Boat Race.