MCV can refer to:

• MCV Bus and Coach, a bus body builder, based in Ely, Cambridgeshire, UK
• Manchester Victoria station, its National Rail station code
• Mean corpuscular volume, a measure of red blood cell count
• Medical College of Virginia, the medical campus of Virginia Commonwealth University
• Mobile Construction Vehicle in the Command & Conquer game series
• Molluscum contagiosum virus, a DNA poxvirus
• Morris Cowley Van, a car-based light van vased on the Morris Oxford (1950-56)
• 1105 (the year or the number) in Roman numerals
• Living Colombia Movement (Movimiento Colombia Viva), a Colombian political party
• Somtaaw Mimic Composite Vehicle A fictional spacecraft from the computer game Homeworld: Cataclysm

McV is a former identity of McVitie's biscuits