Since human recombinants have replaced the animal version in human therapeutics, the prefix of "rh" for "human recombinant" appears less and less in the literature

Human recombinants that replaced animal or harvested from human types

• Human growth hormone (rhGH) Humatrope® from Lilly; and Serostim® from Serono replaced cadaver harvested human growth hormone
• Human insulin (rhI) Humulin® from Lilly replaced bovine and porcine insulin for human therapy
• Follicle-stimulating hormone FSH replaced Serono's Pergonal which was previously isolated from post-menopausal female urine
• Factor VIII Kogenate® from Bayer replaced blood harvested factor VIII

Human recombinants with recombination as only source

• Erythropoietin (EPO) Epogen® from Amgen
• Granulocyte colony-stimulating factor (G-CSF) filgrastim sold as Neupogen® from Amgen; pegfilgrastim sold as Neulasta®
• alpha-glactosidase A Fabrazyme® by Genzyme
• alpha-L-iduronidase (rhIDU; laronidase) Aldurazyme® by BioMarin Pharmaceutical and Genzyme
• N-acetylgalactosamine-4-sulfatase (rhASB; galsulfase) Naglazyme (TM) by BioMarin Pharmaceutical
• DNAse Pulmozyme® by Genentech
• Tissue plasminogen activator (TPA) Activase® by Genentech
• Glucocerebrosidase Ceredase® by Genzyme
• Interferon (IF) Interferon-beta-1a as Rebif® from Serono; Interferon beta-1b as Betaseron® from Schering
• Insulin-like growth factor 1 (ILG)

Animal recombinants

• Bovine somatotropin (bST)

Viral recombinants

• envelope protein of the hepatitis B virus marketed as Engerix-B® by SmithKline Beecham

External links

• Sales of human recombinant proteins

Peptide hormones