Gourt Home::Gourt :: List of human clusters of differentiation
The following is a list of Clusters of Differentiation (or CD) molecules.
| CD1 | an MHC-like molecule that presents lipid molecules |
| CD2 | a type I transmembrane protein found on thymocytes, T cells, and some natural killer cells that acts as a ligand for CD58 and CD59 and is involved in signal transduction and cell adhesion; expressed in T-cell acute lymphoblastic leukemia and T-cell lymphoma. |
| CD3 | the signaling component of the T cell receptor (TCR) complex |
| CD4 | a co-receptor for MHCII; also a receptor used by HIV to enter T cells |
| CD5 | a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma. |
| CD7 | a type I transmembrane protein found on thymocytes, some T cells, monocytes, natural killer cells, and hemopoietic stem cells; expressed in patients with mycosis fungoides, some patients with T-cell acute lymphoblastic lymphoma, and a few patients with acute nonlymphocytic lymphoma. |
| CD8 | a co-receptor for MHCI; also found on a subset of myeloid dendritic cells. |
| CD10 | a type II transmembrane protein found on pre-B cells, germinal-center B cells, some neutrophils, kidney cells, T-cell precursors, and epithelial cells that acts as a zinc metalloprotease cleaving peptide bonds on the amino side of hydrophobic amino acids; expressed in acute lymphocytic leukemia and follicular-center-cell lymphomas. |
| CD11c | a type I transmembrane protein found on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. |
| CD14 | a membrane protein found on macrophages which binds to bacterial lipopolysaccharide. |
| CD15 | a phosphatidylinositol-anchored transmembrane protein found on neutrophils and which may be involved in phagocytosis; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. |
| CD16 | Fc receptor for IgG. Found on NK cells, macrophages, and neutrophils. |
| CD19 | B-lymphocyte surface antigen B4 |
| CD20 | a type III transmembrane protein found on B cells that forms a calcium channel in the cell wall allowing for the influx of calcium required for cell activation; expressed in B-cell lymphomas, hairy cell leukemia, and B-cell chronic lymphocytic leukemia. |
| CD21 | a type I transmembrane protein found on B cells, follicular dendritic cells, pharyngeal and cervical epithelial cells, some thymocytes, and some T cells that plays a role in signal transduction; expressed in hairy cell leukemia, B-cell lymphoma, and some T-cell acute lymphocytic leukemias. |
| CD21 | a type I transmembrane protein found in the cytoplasm of pre-B cells and on the surface of mature B cells that facilitates signal transduction; expressed in patients with hairy cell leukemias and in some with B-cell lymphomas. |
| CD23 | a type II transmembrane protein found on mature B cells, monocytes, activated macrophages, eosinophils, platelets, and dendritic cells that enhances capture and processing of antigen complexed with IgE. |
| CD24 | a glycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 3p26, 15q21, 15q22, 20q11.2 and Yq11.1. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined (source: NCBI). |
| CD25 | a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, and neuroblastomas. |
| CD28 | present on all T-cells, and when matched with the appropriate ligand, labeled B7 which can be either CD80 or CD86, it has costimulatory effect on the T-cell. It is also expressed on Eosinophil granulocytes, especially after tissue infiltration. There it's ligation leads to release of potent neurotoxins, IL-2 and IL-13 as well as IFN-γ |
| CD30 | a type I transmembrane protein present on activated T and B cells that may play a role in cell activation and/or differentiation; expressed in Hodgkin disease, some T-cell lymphomas, and anaplastic large cell lymphomas. |
| CD31 | PECAM-1, a cell adhesion molecule on platelets and endothelial cells |
| CD34 | stem cell marker, adhesion, found on hematopoietic precursors (found in high concentrations in umbilical cord blood), capillary endothelium, and embryonic fibroblasts |
| CD35 | Complement receptor 1 (C3b/C4b receptor) |
| CD36 | Platelet glycoprotein IV or IIIb (GP IV / GP IIIb) |
| CD38 | involved in ecto-ADP-ribosyl cyclase and cell activation on many hematopoietic, plasma, and B & T activated cells; marker increases with HIV seroconversion, coexpression with CD8 associated with progression (indicates persistent viral stimulation) |
| CD41 | The platelet glycoprotein (GPIIb/IIIa) integrin acts as a receptor for fibrinogen and several other extracellular matrix molecules. Its absence causes an extremely rare disorder of the blood known as Glanzmann's thrombasthenia. |
| CD45 | leucocyte common antigen, a type I transmembrane protein present on all hemopoietic cells except erythrocytes that assists in cell activation; expressed in lymphomas, B-cell chronic lymphocytic leukemia, hairy cell leukemia, and acute nonlymphocytic leukemia. |
| CD55 | Complement Decay-Accelerating Factor (DAF): regulatory factor in one of the three pathways of the immune system complement cascade |
| CD56 | NCAM (neural cell adhesion molecule), a marker for natural killer cells and some T-lymphocytes |
| CD58 | a membrane protein present on many hemopoietic cells and fibroblasts that acts as a ligand for CD2 and may be involved in T-cell function. |
| CD59 | Membrane attack complex inhibition factor (MACIF); MAC-inhibitory protein (MAC-IP); Antigen MEM43; Protectin: Immune system complement cascade regulatory factor |
| CD61 | Integrin beta 3 (Itgb3); Glycoprotein IIIa (GPIIIa): fibrinogen receptor; major role is in platelet aggregation.Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. Defects in Itgb3 are causative for Glanzmann's thrombasthenia. |
| CD71 | Transferrin receptor, mediates cellular uptake of iron |
| CD72 | Mediator of B-cell - T-cell interactions |
| CD80 | when binded to CD28 on T-cells, can provide the costimulatory effect; also referred to as B7.1, one of the B7 molecules. |
| CD86 | when binded to CD28 on T-cells, can provide the costimulatory effect; also referred to as B7.2, one of the B7 molecules. |
| CD87 | also referred to as the urokinase type plasminogen activator receptor, provides a binding point for urokinase type plasminogen activator |
| CD89 | FcalphaRI - receptor for IgA |
| CD103 | a type I transmembrane protein present on intestinal intraepithelial lymphocytes, some circulating leukocytes, and some T cells that facilitates adhesion to epithelia; expressed in hairy cell leukemia and some B-cell chronic lymphocytic leukemias. |
| CD117 | c-kit, the receptor for Stem Cell Factor, a glycoprotein that regulates cellular differentiation, particularly in hematopoiesis |
| CD120 | a receptor for Tumour Necrosis Factor, an inflammatory cytokine |
| CD133 | a hematopoietic and CNS stem cell marker |
| CD138 | a plasma cell-surface glycoprotein, known as syndecan-1. Syndecan functions as the alpha receptor for collagen, fibronectin and thrombospondin. |
| CD142 | Tissue factor, a major initiator of blood-clotting |
| CD143 | Angiotensin-converting enzyme |
| CD144 | VE-Cadherin, a calcium-dependent adhesion molecule at intercellular junctions, found mainly in the vascular endothelium. Recent research indicates that CD144 may be present on some leucocytes as well. |
| CDw186 | CXCR6, a G-protein-coupled receptor for the neutrophil-attacting chemokine CXCL6 |
| CD209 | DC-SIGN, C-type lectin receptor found on dendritic cell subsets |
| CD202a | Tie2, the receptor for angiopoietins, a family of angiogenic factors |
| CD235a | Glycophorin, a protein on blood cells |
References
Immunology | Clusters of differentiation | Liste de molécules CD humaines
"List of human clusters of differentiation"