Kwame is a given name originating in Ghana.

• Osei Kwame Panyin - 18th century leader of the Ashanti Confederacy, located in what is today southern and central Ghana
• Kwame Nkrumah - a Ghanaian politician and for a time Life President (originally Francis Nwia-Kofi Ngonloma) and one of the most influential founders of Pan-Africanism.
• Kwame Ture - name adopted by Stokely Carmichael, a Trinidadian-American Black activist and leader of the Student Nonviolent Coordinating Committee and the Black Panther Party to honor Kwame Nkrumah and Ahmed Sékou Touré
• Kwame M. Kilpatrick, the Mayor of Detroit, Michigan
• Kwame Anthony Appiah - a Ghanaian-British philosopher of semantics and racism
• Kwame Holman - a correspondent on The NewsHour with Jim Lehrer
• Kwame Jackson - one of the two final candidates on Donald Trump's American television reality series The Apprentice.
• Kwame Kwei-Armah - the name used by a British actor and presenter
• Kwame Brown - a basketball player in the NBA
• Kwame (Captain Planet character), a character in the television series Captain Planet and the Planeteers

Given names