Kesh may refer to:

• the former name of Shahrisabz, Uzbekistan
• Kesh, County Fermanagh, a small village in Northern Ireland
• Kesh (Sikhism), a practice of not cutting hair in Sikhism
• a fictional human culture and language in Ursula K. Le Guin's novel Always Coming Home
• The Empire of Great Kesh, a nation of the world of Midkemia in books written by Raymond Feist