There are several famous people with the name James Mitchell:

• James Mitchell (actor), who has played Palmer Cortlandt on All My Children since 1979.
• James Mitchell (Canadian politician), legislator from New Brunswick.
• James Mitchell (Australian politician), Premier and Governor of Western Australia.
• J. Clyde Mitchell (1918 - 1995) the British social anthropologist.
• James Coffield Mitchell U.S. Congressman from Tennessee from 1825 until 1829.
• Sir James Fitz-Allen Mitchell, Former Prime Minister of Saint Vincent and the Grenadines.
• James S. Mitchell U.S. congressman from Pennsylvania from 1821 to 1826.
• James William Mitchell, a British author, often wrote under the pseudonym James Munro.
• The Rev. James Mitchell, Commissioner of Emigration for President Abraham Lincoln.
• James Mitchell (athlete), American athlete at the 1904 Summer Olympics.
• James Mitchell (author), spy fiction writer best known for creating the television series Callan.
• James Mitchell (wrestler), Pro wrestling manager.
• James Paul Mitchell (1900 - 1964) the US politician.
• James Mitchell (deafblind) (1795-1869) congenitally deafblind son of Scottish minister