Hyginus can refer to:

• Gaius Julius Hyginus (c. 64 BC - 17 AD), Roman poet, author of Fabulae and De Astronomia; reputed author of Poeticon astronomicon
• Hyginus Gromaticus, Roman surveyor
• Pseudo-Hyginus, author of De Munitionibus Castrorum formerly attributed to Hyginus Gromaticus
• Hyginus of Cordova, bishop of present-day Cordoba, 4th-century opponent of Priscillian
• The Hyginus cleft, a surface feature of Earth's moon
• Pope Hyginus, saint

Hyginus | Higinio | Hygin | Hyginus