Erythrocyte (red blood cell or RBC) inclusion: over time Hemoglobin H (Hb H), which is four beta-chains, can become oxidized and/or denatured which then precipitates and causes damage to the RBC membrane. Heinz bodies cannot be seen with Wright stained blood smears, but can be seen when stained with crystal violet. Heinz bodies are frequently seen in α-thalassemia or G6PD (Glucose-6-Phosphate Dehydrogenase) Deficiency. When a macrophage in the spleen "sees" a RBC with a Heinz Body, it removes the precipitate and a small piece of the membrane, leading to characterisitc "bite cells".

Small irregular, deep purple granules in red blood cells due to damage of the haemoglobin molecules. Seen in premature infants, in certain forms of drug sensitivity, characteristically in glucose-6-phosphate dehydrogenase deficiency following administration of oxidant drugs, e.g. primaquin. Also in certain type of hereditary haemolytic anaemia, especially in patients with thalassaemia. The bodies are best seen when the blood is stained with crystal violet.

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