He may mean:

• He, a third person singular pronoun for a person of male gender, or, in traditional English grammar, a person of unknown gender.
• He (letter), the fifth letter of many Semitic alphabets, including the Hebrew, Phoenician, and Aramaic
• He (Cyrillic) ( Г, г ), the fourth letter of the Ukrainian and Belarusian alphabets
• He (song), a popular song from 1955
• He, an alternative name for the game of tag
• Hé, the pinyin romanization of several Chinese surnames, also romanized as Ho (surname)
• Chinese admiral Zheng He

Abbreviations:

• Helium (He), symbol for the chemical element
• Hebrew language (ISO 639 alpha-2, he)
• Luftfahrtgesellschaft Walter (IATA airline code HE)
• High explosive (HE)
• His Excellency or Her Excellency (HE)
• Higher education (HE)
• Hockey East, a division in NCAA hockey Division I
• Hollis and Eastern Railroad (AAR reporting mark HE)
• H&E stain (haematoxylin and eosin stain)
• Humongous Entertainment a software company that produced interactive educational games largely for children.

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