Haemophilia C is a mild form of hemophilia affecting both sexes that predominantly occurs in Jews of Ashkenazi descent. It is due to deficiency of coagulation factor XI. It can be distinguished from haemophilia A and B as it does not lead to bleeding into the joints. Furthermore, it has autosomal recessive inheritance, the gene for factor XI located on chromosome 4 (close to the prekallikrein gene). Many mutations exist, and the bleeding risk is not always influenced by the severity of the deficiency. Treatment is usually not necessary, except in relation to operations, leading to many of those having the condition not being aware of it. In these cases, FFP or recombinant factor XI may be used, but only if necessary.

Congenital genetic disorders | Blood disorders