Guthrie may refer to the following places:

• Guthrie, Oklahoma
• Guthrie, Kentucky
• Guthrie County, Iowa
• Guthrie, Texas
• Guthrie, Angus

and to the following people

• Arlo Guthrie, folk singer;
• Woody Guthrie, folk singer (and father of Arlo Guthrie);
• Malcolm Guthrie, professor of Bantu languages
• Francis Guthrie, a mathematician famous for first stating the four color problem;
• Samuel Guthrie (1782-1848), physician, discoverer of chloroform;
• Thomas Guthrie, a 19th century philanthropist;
• Sir Tyrone Guthrie, English stage director, playwright, founder of Guthrie Theater
• Frederick Guthrie, British scientific writer and professor;
• Hugh Guthrie, a Canadian politician and Cabinet minister

Guthrie is also a Malaysian plantation company.

Guthrie