The word guess can refer to the following:

• Guess?, the name-brand clothing line that uses a question mark as its emblem. It's known for its sexualized advertising campaigns, which have featured mostly black and white photographs of models and actresses such as Claudia Schiffer, Drew Barrymore, and Anna Nicole Smith.

• A conjecture or estimation.
• The GUESS Protocol of Gnutella
• A popular Taiwanese variety program, hosted by Jacky Wu, Rainie Yang and A-Ya.