Guajira may refer to:

• Guajira, a style of Cuban music, song or dance
• Guajira, a governmental department of the country Colombia.
• Guajira Peninsula, a peninsula at the northernmost point of South America, split between the countries of Colombia and Venezuela.
• Guajira Indians, a tribe of indians indiginous to the Guajira Peninsula.
• Guajira, a country woman or girl