Gridiron can mean many different things:
- Gridiron football — either the field on which a football game is played, or the game itself (American and Canadian football)
- In urban planning, a gridiron plan system describes an ordered arrangement of streets in a regular grid pattern, intersecting at right angles
- In theatres, the gridiron is a metal framework suspended above the stage from which lights and other items are hung
- A gridiron (cooking) is also a type of grill that can be used to cook meat or other food over a fire
- A gridiron pendulum is a part of a pendulum clock as designed by John Harrison
- Gridiron (science fiction story) — a story about a semi-intelligent large office building going wild, because it is infected by intelligent malevolent virus software
- Gridiron Club - a journalistic organization in Washington, D.C., USA