The term Great Lakes usually refers to:

• The North American Great Lakes and the Great Lakes region (North America)
• The African Great Lakes and the region

It can also refer to:

• Great Lakes, New South Wales, Australia
• Great Lake, Tasmania, Australia
• Great Lake (Britain), on the River Poulter in Nottinghamshire
• Great Lakes (band), a project of the Elephant Six Collective
• Great Lakes Brewing Company, based in Cleveland, Ohio
• Naval Station Great Lakes, a United States Navy base located north of Chicago, Illinois and home to the US Navy's Recruit Training Command and numerous other commands

Some other lakes are called "Great".

• Great Bear Lake is the largest lake in the Northwest Territories of Canada and fourth largest in North America
• Great Slave Lake is the second-largest lake in the Northwest Territories of Canada
• Great Salt Lake is the largest lake in Utah in the United States
• Great Salt Plains Lake is a manmade lake in Oklahoma in the United States
• Great Sacandaga Lake is a lake in the Adirondack Mountains of New York in the United States
• Great Bitter Lake on the Suez Canal in Egypt

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