Gordon Henry Guyatt (born 1953) is a physician and Professor of Clinical Epidemiology & Biostatistics at McMaster University in Hamilton, Ontario. He is known for his work on evidence-based medicine, a term that first appeared in a paper he published. Guyatt G, Cairns J, Churchill D, et al. Medicine Working Group’ "Evidence-based medicine. A new approach to teaching the practice of medicine." JAMA 1992;268:2420-5. PMID 1404801 He has published over 450 peer-reviewed articles in medical journals. He has also written extensively on health care policy in the popular press.

In 1979, Guyatt and Dr. Fred Freedman co-founded the Medical Reform Group, a Canadian organization of physicians, medical students and others which supports universal public health care. Guyatt continues to serve as a member of the steering committee and leading spokesperson for this group.

Guyatt ran as the New Democratic Party (NDP) candidate in the 2004 and 2006 Canadian federal elections in the riding of Ancaster—Dundas—Flamborough—Westdale, finishing in third place but exceeding 20% of the popular vote in each attempt. He previously ran for the NDP in the 2000 federal election in the former riding of Ancaster—Dundas—Flamborough—Aldershot, finishing in fourth place with approximately 8% of the vote.

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