Glycopyrrolate is a medication of the muscarinic anticholinergic group. It is a synthetic quaternary amine with no central effects and is available in oral and intraveinous (i.v.) forms, although oral absorption is less than 5%.

Medical uses

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Glycopyrrolate blocks peripheral muscarinic receptors, thus inhibiting cholinergic transmission.

In anesthesia, glycopyrrolate injection can be used as a preoperative medication on order to reduce salivary, tracheobronchial, and pharyngeal secretions, as well as decreasing the acidity of gastric secretion. It is also used in conjunction with neostigmine, a neuromuscular blocking reversal agent, to prevent neostigmine's muscarinic effects such as bradycardia.

It decreases acid secretion in the stomach and so may be used for treating stomach ulcers, in combination with other medications.

Side effects

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Glycopyrrolate reduces the body's sweating ability, can even cause fever and heat stroke in high temperatures. Dry mouth, difficult urinating, headaches, diarrhea and constipation are also observed side effects of the medication.

The medication also induces drowsiness or blurred visions, an effect exacerbated by the consumption of alcohol.