George Wolfe may refer to:

• George C. Wolfe (born 1954), African-American playwright and director
• George Wolfe (Irish politician) (died 1941), Irish Cumann na nGaedhael TD 1923–1932
• George Wolfe (CPA), US government administrator in Iraq
• George Wolfe (cartoonist)
• George Wolfe (basketball coach), men's basketball head coach at Long Island University, U.S.A., 1943-45

See also:

• George Wolf (1777–1940), governor of the U.S. state of Pennsylvania