Gardner's syndrome is a condition affecting the digestive tract. It is a syndrome of multiple polyposis that predisposes a patient to colon cancer. Other abnormalities, such as osteomas of the skull, thyroid cancer, epidermoid cysts, and fibromas, are also associated with this syndrome. Malignant transformation occurs in 100% of polyps of persons with Gardner's syndrome.

Gardner's Syndrome displays autosomal dominant inheritance, as it is caused by a mutation of the adenomatous polyposis coli (APC) gene on chromosome 5q. As such, it bears resemblance to familial adenomatous polyposis (FAP).

Diseases | Gardner-Syndrom | Syndrome de Gardner