GRB7, Growth factor Receptor-Bound protein 7 is an SH2-domain adaptor protein that binds to Receptor-tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias her2/neu) proto-oncogene. These two genes are commonly co-amplified (prescent in excess copies) in breast cancers. GRB7, thought to be involved in migration, is well known to be over-expressed in testicular germ cell tumors, esophagous cancers, and gastric cancers.

Proteins