GIS can refer to:

• Gas insulated switchgear for electric power distribution
• Geodesic interpolating splines in image registration.
• Geographic information system, a system for creating, storing, analyzing and managing spatial data and associated attributes
• Geographic information science
• Gisborne Airport (IATA airport code: GIS) in Gisborne, New Zealand
• Google Image Search, the image finding capability of search engine Google
• Gruppo di Intervento Speciale, a counter-terrorist unit of the Italian Carabinieri
• Groupe d'Intervention Spécial, a special operations unit of Algeria
• Old Age Security-Guaranteed Income Supplement, a Canadian pension plan is a taxable monthly payment available to most older Canadians

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