The Friedländer synthesis is the chemical reaction of 2-aminobenzaldehydes with ketones to form quinoline derivatives.

Several reviews have been published.

References

1. Organic Syntheses, Coll. Vol. 3, p.56 (1955); Vol. 28, p.11 (1948). (Article)
2. Friedländer, P. Ber. 1882, 15, 2572.
3. Friedländer, P.; Gohring, C. F. Ber. 1883, 16, 1833.
4. Manske, R. H. Chem. Rev. 1942, 30, 124. (Review)
5. Bergstrom, F. W. Chem. Rev. 1944, 35, 151. (Review)
6. Cheng, C. C.; Yan, S. J. Org. React. 1982, 28, 37. (Review)

See also

• Niementowski quinoline synthesis
• Pfitzinger reaction

Organic reactions