The FAS ligand or FasL is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family.

Some alternate names include Fas ligand, FasL,Apo1, apoptosis antigen ligand 1, CD95 ligand. It is a trimeric molecule.

FasL will bind to 3 monomers of FAS which are spanning the membrane of the "target" cell. This trimerization will possibly leading to apoptosis, or cell death.

Defective Fas mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

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Signal transduction