Echothiophate is a parasympathomimetic and organophosphate which binds irreversibly to cholinesterase. Because of the very slow rate at which echothiophate is hydrolyzed by cholinesterase, its effects can last a week or more.

Clinical uses

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Echothiophate is used as ocular drops in the treatment of chronic glaucoma. It is available under several trade names such as Phospholine Iodide (Wyeth-Ayerst).

Sources

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• Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
• Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

External links

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Anticholinesterases | Esters | Organophosphates | Ophthalmology