Depurination is DNA alteration in which the hydrolysis of a purine base (Adenine or Guanine) from the deoxyribose-phosphate backbone occurs. After a depurination, the sugar phosphate backbone remains and the sugar ring has a hydroxyl (-OH) group in the place of the Adenine or Guanine.

Reference

---

Hartwell, Hood, Goldberg, Reynolds, Silver, Veres. Genetics: From Genes to Genomes. Second Edition. McGraw-Hill Companies Inc. New York, NY: 2004.

Mutation dert