De Soto is the name of several places in the United States of America presumably all named for the explorer Hernando de Soto:

• De Soto, Georgia
• De Soto, Illinois
• De Soto, Iowa
• De Soto, Kansas
• De Soto, Mississippi
• De Soto, Missouri
• De Soto, Nebraska
• De Soto, Wisconsin (two places):
  • in Crawford County
  • in Vernon County
• De Soto Parish, Louisiana
• Fort De Soto Park in St. Petersburg, Florida

De Soto is also the name of several famous people:

• Álvaro de Soto - Peruvian diplomat and UN special envoy.
• Domingo de Soto - 16th century Spanish theologian
• Luis Barahona de Soto - Spanish poet.
• Hernando de Soto (economist) - Peruvian economist and author.
• Hernando de Soto (explorer) - Spanish conquistador.
• Serafín María de Soto - Prime minister of Spain.

(There are also places named DeSoto, without the space in the name.)

De Soto was also the name of an automobile brand manufactured by Chrysler Corporation.

De Soto