de Quervain's thyroiditis, also known as subacute granulomatous thyroiditis, usually occurs in females between 30 and 50 years of age. It is believed to be viral in origin, being usually preceded by a upper respiratory tract infection. Patients will experience a transient hyperthyroid state (extravasation of colloid), with pain and fever. However, symptoms are fluctuant. Treatment is NSAID. Corticosteroids may be of help in refractory cases.